Dr S.B.A. Cohen

Peer Reviewed Scientific Publications

Autoimmune Diseases

  1. T cell clones from Sjogrens syndrome salivary gland produce high levels of IL-10 (1996). Clin. Exp. Immunol. 103, 268-272.
  2. High IL-10 production by the activated T cell population within the rheumatoid membrane (1995). Arthritis and Rheumatism. 38, 946-952.
  3. Identification of thyroid stimulating hormone receptor-specific T cells in Graves' disease thyroid using autoantigen-transfected Epstein-bar virus-transformed B cell lines(1995). J. Clin. Invest. 96, 30-37.
  4. Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis(1994). J. Clin. Invest. 94, 749-760.14.
  5. The effect of T cell subset depletion in autoimmune thyroiditis (1990). Immunol. Lett. 23, 263-268.
  6. T cell receptor phenotypes in autoimmune thyroid disease(1990). J. Endocrinol. Invest. 13, 339-342.
  7. Serological analysis of experimental autoimmune thyroiditis(1990). Int. Arch. Allergy and Clin. Immunol. 91, 47-53.
  8. Immunohistochemical analysis of retrobular tissue in Graves ' Opthalmopathy (1989). Clin. Exp. Immunol. 75, 222-227.
  9. Expression of an intracellular adhesion molecule, ICAM-1, by human thyroid tissue( 1989). J. Endocrinol. 122, 185-191.
  10. Affinity purification of IgG subclasses and the distribution of thyroid autoantibodies from patients with Hashimoto's thyroiditis (1989). Scand. J. Immunol. 30, 73-82.
  11. Terminal complement complexes and C1\C1 inhibitor complexes in autoimmune thyroiditis (1989). Clin. Exp. Immunol. 77, 25-30.
  12. Anti-thyroid drugs ameliorate thymectomy-induced experimental autoimmune thyroiditis (1998). Autoimmunity. 1, 57-58.
  13. Sequential analysis of experimental autoimmune thyroiditis(1998). Cell. Immunol. 114, 126-136.
  14. The effect of iodine depletion and supplementation (1998). J. Endocrinol. Invest. 11, 625-627.
  15. Activated interstitial and intraepithelial lymphocytes in autoimmune thyroiditis (1998). Acta Endocrinol. 119, 161-166.
  16. The relationship of HLA-DR3 and the outcome after anti-thyroid drugs and the distribution of thyroid autoantibodies in Graves' disease (1987). Acta Endocrinol. 114, 292-297.
  17. Characterisation of different types of autoimmune thyroiditis (1987) Clin. Exp. Immunol. 69, 25-32.
  18. The IgG subclass distribution of thyroid autoantibodies (1986). Immunol. Lett. 13, 335-341.
Placental Blood and Pregnancy
  1. The effect of cord blood sera on CD69 expression (2002). Immunol Lett 84(1), 77-80,
  2. Macrophage Colony Stimulating Factor (M-CSF) within cord blood sera may be partially responsible for the reduced proliferation of cord blood T cells (2000). Eur Cyt Net 11(4):608-617
  3. Naive T cells from cord blood have the capacity to make type 1 and Type 2 cytokines (2000). Immunology Letters 75 (1), 85-88
  4. Cord blood serum does not increase lymphocyte responses in comparison to adult serum (2000). Human Immunology 61 111-114
  5. Cord blood (CB) lymphocytes have a low frequency of cytokine producing T cells due to a high threshold For Activation (2000) Immunology Letters 72, 145-146
  6. Can Cord Blood Cells Support The Cytokine Storm In GvHD? (2000) Cytokine and Growth Factor Reviews 11, 185-197
  7. Analysis of the cytokine production by cord and adult blood.(1999) Human Immunol. 60, 331-336.
  8. Produccion de citocinas por linfocitos de cordon umbilical. Relacion con el transplante alogenico de celulas multipotenciales.(1999) Hematol. Citocinas Inmunoter. Ter. Cel. 2:6 425-233
  9. The Immunological properties of cord blood: Overview of current research presented at the 2nd EUROCORD Workshop (1998). Bone Marrow Transpl. 22, S1 22-25
  10. Foetal Natural Killer cell function is suppressed (1998). Immunology 94, 109-114
  11. Foetal lymphocytes are more sensitive to freezing than adult lymphocytes within a mononuclear cell environment (1998) Bone Marrow Transpl. 22, S1, 41-43
  12. Immunological and functional differences between cord and peripheral blood(1998). Bone Marrow Transpl. 21, S3, 9-12
  13. Does cord blood transplantation result in lower graft-versus-host disease? It takes more than two to tango (1997). Human Immunol. 56 , 1-5.
  14. Natural killer cell function is altered by freezing in DMSO(1997). Biochem. Trans., 25, 175
  15. Effect of 50 ATA helium pressure at different stages of pregnancy(1987). J. Appl. Physiol. 62, 978-982.
  16. A comparison of fertility in vitro and in vivo after exposure to 50 ATA pressure (1986). Gam. Res. 13, 143-149.
Pure Immunology
  1. How should we present our cytokine profile data? (2000) Immunology Today 21, 199
  2. Soluble CD8 stabilises the HLA class I molecule by promoting b2m exchange: analysis in real-time(1999) . Human Immunology 60, 442-229
  3. Real-time analysis of cell surface HLA class I interactions(1998). Biosensors and Bioelectronics 13, 1099-1105
  4. The influence of exogenous peptide on b2-microglobulin exchange in the HLA complex: analysis in real time(1998). Immunogenetics 48: 98-107
  5. Autocrine and paracrine regulation of human IL-10 production(1997). J. Immunol. 158, 5596-5602
  6. IL-10 rescues T cells from apoptotic cell death: association with an upregulation of Bcl-2(1997). Immunol.92, 1-5
  7. The method of obtaining T cell clones alters the IL-10 production(1996). Immunol. 87, 343-347.
  8. IL-10 and IL-3 synergies to cause proliferation of human T cells(1995). Immunol. 85, 351-356.
  9. Human a/ß T cell receptor CD4- CD8- T cell clones are predominantly Th0-like(1995). Immunol. 84, 501-504.
  10. Are CD4+ Th1 cells pro-inflammatory or anti-inflammatory? The ratio IL-10 to IFNg or IL-2 determines their function(1995). Int. Immunol. 7, 1287-1294.
  11. IL-10 enhances expression of the IL-2 receptor a chain on T cells (1994). Immunol. 83, 329-332.
  12. The control of class II expression on T cells is independent of the regulation of Tac and the induction of proliferation (1991). Clin. Exp. Immunol. 86, 544-549
Renal Dialysis
  1. Effect of renal dialysis therapy modality on T cell cytokine production. (1999) Nephrology, Dialysis, Transplantation 14, 49-55
  2. The frequency of Th2 type cells increases with time on peritoneal dialysis in patients with diabetic nephropathy.(1999) Eur. Cyt. Net 10, 219-226
Vaccines
  1. The influence of host factors and immunogenetics on lymphocyte responses to Hepagene vaccination.(1999) Vaccine 17, 1329-1337
  2. Human leukocyte antigens influence the immune response to a Pre-S/S hepatitis B vaccine.(1999) Vaccine 17, 330-339
  3. Hepatitis B Third Generation Vaccines: Improves Response And Conventional Vaccine Non-Response - Evidence For Genetic Basis In Man (1998).Journal of Viral Hepatitis 5, (S2) 9-11.

Examples of Presentations at International Meetings

Examples of Chairing

  1. Antigen presenting cell and T cell sessions at "The 2nd UK Cord Blood Immunology Group Meeting" (Oct 2001), Newcastle, UK
  2. The 1st UK Cord Blood Immunology Group Meeting (Sept 2000), London , UK .
  3. The 4th Central European Transplant Meeting, Prague , The Czech Republic (Nov 1999). Cord Blood Transplantation Session
Examples of presentations of scientific research
  1. Analysis of effector cells involved in graft versus host disease (GvHD) in bone marrow (BM) graft recipients using an in vitro skin explant model. EBMT Meeting, Montreux ( Switzerland ), 24-27.03.2002
  2. Cord Blood (CB) serum influences CD69 expression,British Society of Immunology meeting in Harrogate , Neonatal Immunity session (Abstract No. 17.8)Thursday 6th December 2001
  3. Cord blood (CB) serum affects the phenotype and function of NK cells, 2nd Annual UK Cord Blood Immunology group meeting, Newcastle , UK , October 26th 2001
  4. Characterisation of T Cells Involved in Cutaneous GvHD of Allogeneic Bone Marrow Transplant Recipients Using an In Vitro Skin Explant Model, The American Society of Hematology Meeting, ( USA ) 12th October 2001
  5. Cord blood serum enhances reactivity of T cells to IL-2. EFIS Meeting, Poznan ( Poland ), 23-27 September 2000
  6. The phenotypic characteristics of cord blood (CB) natural killer (NK) cells are not comparable to adult NK cells: Role of the microenvironment. EFI Meeting, Montpallier (France), 4-7 April 2000
  7. Serum from cord blood (CB) enhances T cell reactivity to IL-2. EBMT Meeting, Innsbruck ( Austria ), 5-8 March 2000
  8. The microenvironment that the cord blood T cells are derived from is partially responsible for the cells reduced function. BSI Meeting, Harrogate , 30 November - 3 December 1999
  9. Can Cord Blood Really Give A Lower GvHD Response than Bone Marrow When Used For Stem Cell Translation? Forum For Experimentall Ochh Klinisk Hematologi, Lund , Sweden (Nov 1999)
  10. The immunological properties of cord blood. The 4th Central European Transplant Meeting, Prague , The Czech Republic (Nov 1999)
  11. Cord Blood Serum Causes Reduced Lymphocyte Responses: Role In Stem Cell Transplantation. The 4th Central European Transplant Meeting, Prague , The Czech Republic (Nov 1999)
  12. The cellular microenvironment may explain the reduced lymphocyte responses of cord blood. 2nd Congress of Tissue Banking and 8th International Conference of EATB Warsaw , 6-10 October 1999
  13. Cord blood (CB) lymphocytes have a low frequency of cytokine producing T cells due to a high threshold for activation. ISICR (International Society for Interferon and Cytokine Research) Meeting, Paris, 5-9 September 1999
  14. The cellular microenvironment may explain the reduced lymphocyte responses of cord blood. 13th EFI Meeting, Crete , 13-17 April 1999
  15. The phenotypic and functional characteristics of cord blood (CB) natural killer (NK) cells are not comparable to adult NK cells. X BSHI Meeteing, Harrogate , 10-12 February 1999
  16. Does the cellular microenvironment explain the reduced cytokine production of cord blood lymphocytes?X BSHI Meeteing, Harrogate , 10-12 February 1999 Eur J Immunol, 1999, 26 (1), 54.
  17. The Immunobiology Of Cord Blood T Cells. 6th AOH/ASEATTA Meeting, New Delhi , India (Nov 1998):
  18. The Frequency Of Th2 Type Cells Is Increased With Time On Peritoneal Dialysis In Patients With Diabetic Nephropathy. Xth International Congress of Immunology. New Delhi , India (Nov 1998).
  19. The Immunology Of Cord Blood Lymphocytes (Plenary session). Eurocord Transplant Workshop Meeting. Annecy , France (May 1998).
  20. The European School of Haematology. The Fourth Tutorial on Histocompatability, London , UK (May 1998).
  21. Cord Blood Serum Lacks A T Cell Activation Factor That Is Present In Adult Serum. Eurocord Transplant Workshop Meeting. Annecy , France (May, 1997):
  22. The Role Of Cord Blood In Transplantation. Department of Clinical Laboratory Sciences, Queens Medical Centre, University of Nottingham , UK (Feb 1997):
  23. Are Cord Blood Mononuclear Cells Sensitive To Freezing? Eurocord Transplant Workshop Meeting. Annecy , France (May, 1996).
  24. A Subpopulation Of Infiltrating T Cells Producing Large Amounts Of IL-10 Within The Autoimmune Target May Be Important In Endogenous Immunosuppression.IXth International Congress of Immunology. Autoimmune pathogenesis and treatment (human disease) workshop. San Francisco , U.S.A. (July, 1995).
  25. T Cell Clones Obtained From The Joints Of Rheumatoid Arthritis Patients Produce High Levels Of IL-10. European Workshop for Rheumatology. Gent , Belgium (March, 1994)
  26. IL-10 Has Differential Effects On The IL-2 Dependent Proliferative Response Of CD4+ T Cell Clones. British Society Of Immunology. Southampton , UK . (March, 1994).

Examples of Book Contributions

Books

Cord Blood Characteristics: Role In Stem Cell Transplantation Ed: S.B.A. Cohen, E. Gluckman, P. Rubinstein, J.A. Madrigal. Pubs: M. Dunitz, Lond. UK (2000).
Book Chapters
  1. T cells and cytokines. In: Cytokines (3rd edition): A Practical Approach. Ed: F. Balkwell. Oxford University Press. (2000). 51-68
  2. Cord Blood T Cells. In: CB Characteristics: Role In Stem Cell Transplantation. Ed: S.B.A. Cohen, E. Gluckman, P. Rubinstein, J.A. Madrigal. M. Dunitz, Lond. UK , 39-59 (2000).
  3. Cord Blood Cytokines. In: CB Characteristics: Role In Stem Cell Transplantation. Ed: S.B.A. Cohen, E. Gluckman, P. Rubinstein, J.A. Madrigal. M. Dunitz, Lond. UK , 73-96 (2000).
  4. Homeostatic regulatory mechanisms in rheumatoid arthritis synovium: Interleukin-10 is the major anti-inflammatory cytokine. In: Horizons in Medicine no. 7. Ed: S. Lightman. Blackwell Science, 343-351 (1996).
  5. T cells and cytokines. In: Cytokines (2nd edition): A Practical Approach. Ed: F. Balkwell. Oxford University Press, 179-196. (1995).
  6. The IgG subclass distribution of thyroid autoantibodies in Graves' disease. In: Thyroid Autoimmunity, Ed: Pinchera A. Plenum Press, New York , 301-303.(1988).
  7. Immunohistochemical characterisation of lymphocytes in autoimmune thyroiditis. In: Thyroid Autoimmunity, Ed: Pinchera A. Plenum Press, New York , 331-334 (1988).
Book Series
Series Editor for Euroscicon Published Proceedings (2006 - 2008)

Examples of Scientific Reviews

  1. After-Life of the Afterbirth. Summary of the Inaugaral meeting of the UK Cord Blood Immunology Group
  2. Proceedings of the 2000 Annual UK Cord Blood Immunology Group (2000)
  3. Can Cord Blood Cells Support The Cytokine Storm In GvHD? Cytokine and Growth Factor Reviews 11, 185-197 (2000)
  4. Produccion de citocinas por linfocitos de cordon umbilical. Relacion con el transplante alogenico de celulas multipotenciales. Hematol. Citocinas Inmunoter. Ter. Cel. 2:6 425-233 (1999)
  5. Analysis of the cytokine production by cord and adult blood. Human Immunol. 60, 331-336. (1999).
  6. The Immunological properties of cord blood: Overview of current research presented at the 2nd EUROCORD Workshop. Bone Marrow Transpl. 22, S1 22-25 (1998).
  7. Hepatitis B Third Generation Vaccines: Improves Response And Conventional Vaccine Non-Response - Evidence For Genetic Basis In Man.Journal of Viral Hepatitis 5, (S2) 9-11.(1998).
  8. Does cord blood transplantation result in lower graft-versus-host disease? It takes more than two to tango. Human Immunol. 56, 1-5. (1997).